ONLINE: https://tinyurl.com/NanoColloquia
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Speaker: Mariacristina Gagliardi - Cnr Nano
Title: "Advancing acoustic biosensing: functionalization strategies and applications in diagnostics, agrifood, and nanomedicine".
Acoustic biosensors are increasingly gaining attention across a wide range of applications, from biomedical diagnostics to green technologies and the agrifood sector. Their versatility and sensitivity make them invaluable tools for detecting biomolecules, pollutants, and food-related analytes. However, the chemical functionalization of sensor surfaces remains a critical challenge for enhancing detection performance, selectivity, and stability.
This talk will illustrate some practical examples of how to achieve accurate detection of peptides, proteins, and enological molecules of interest, exploring also applications where the surface properties of nanoparticles are tested. Finally, we will illustrate the integration of acoustic sensors with molecularly imprinted nanoparticles, used as bioreceptors for the analysis of proteins, nucleic acids, and enological polyphenols.
By addressing these diverse yet interconnected applications, we demonstrate the critical role of surface chemistry in advancing acoustic biosensing technologies. These advancements promise to pave the way for more effective diagnostic tools, sustainable practices in the agrifood industry, and innovative solutions in nanomedicine.
References
1. Agostini, M., Lunardelli, F., Gagliardi, M., Miranda, A., Lamanna, L., Luminare, A. G., ... Cecchini, M. (2022). Surface‐acoustic‐wave (SAW) induced mixing enhances the detection of viruses: application to measles sensing in whole human saliva with a SAW lab‐on‐a‐chip. Advanced Functional Materials, 32(44), 2201958;
2. Gagliardi, M., Colagiorgio, L., Cecchini, M. (2023). A fast and reliable method based on QCM-D instrumentation for the screening of nanoparticle/blood protein interactions. Biosensors, 13(6), 607;
3. Gagliardi, M., Agostini, M., Lunardelli, F., Miranda, A., Luminare, A. G., Cervelli, F., ... Cecchini, M. (2022). A surface acoustic wave (SAW)-based lab-on-chip for the detection of active α-glycosidase. Biosensors, 12(11), 1010;
4. Gagliardi, M., Agostini, M., Lunardelli, F., Lamanna, L., Miranda, A., Bazzichi, A., ... Cecchini, M. (2023). Surface acoustic wave-based lab-on-a-chip for the fast detection of Legionella pneumophila in water. Sensors and Actuators B: Chemical, 379, 133299;
5. Gagliardi, M., Tori, G., Agostini, M., Lunardelli, F., Mencarelli, F., Sanmartin, C., Cecchini, M. (2022). Detection of oenological polyphenols via QCM-D measurements. Nanomaterials, 12(1), 166;
6. Gagliardi, M., Tori, G., Sanmartin, C., Cecchini, M. (2025). The effect of probe density coverage on the detection of oenological tannins in quartz crystal microbalance with dissipation monitoring (QCM‐D) experiments. Journal of the Science of Food and Agriculture, 105(3), 1476-1483.
Host: Fabio Taddei